Understanding Crohn's Disease: Advancing Research and Enhancing Patient Care

At FOMAT Medical Research, we are dedicated to improving treatment options for Crohn's Disease through comprehensive clinical trials. Our goal is to assist those seeking new therapies and foster collaboration in clinical research to advance the understanding and management of this chronic condition.

Understanding Crohn's Disease

About Crohn's Disease

Crohn's Disease is a chronic inflammatory condition of the gastrointestinal tract, classified under inflammatory bowel diseases (IBD), which also includes Ulcerative Colitis. Unlike Ulcerative Colitis, which is limited to the colon and rectum, Crohn's Disease can affect any part of the digestive tract from the mouth to the anus. This inflammation can extend through multiple layers of the intestinal walls, leading to a range of symptoms and complications.

Crohn’s Disease is a chronic inflammatory condition of the gastrointestinal tract, part of inflammatory bowel diseases (IBD), including Ulcerative Colitis. It can affect any part of the digestive tract from mouth to anus, causing various symptoms and complications.

Symptoms of Ulcerative Colitis

  • Abdominal Pain and Cramping: Due to inflammation and ulceration of the digestive tract.
  • Persistent Diarrhea: Resulting from the body’s inability to absorb nutrients properly.
  • Fatigue: Often due to the body’s response to chronic inflammation.
  • Weight Loss and Reduced Appetite: Caused by digestive issues and discomfort during eating.

Causes and Risk Factors of Crohn's Disease

Overview of Potential Causes

The precise cause of Crohn's Disease remains unknown, but it is thought to involve an interplay of genetic, immune, and environmental factors.

Genetic Predisposition

A family history of Crohn's Disease increases risk, indicating a genetic component in susceptibility.

Environmental Factors and Immune System

Diet, pollution, and stress can trigger or worsen symptoms, highlighting the complex interaction between environment and immunity.

Lifestyle Factors

Smoking, diet, and physical activity levels can influence the disease's course, suggesting lifestyle adjustments as part of a comprehensive treatment plan.

Complications of Crohn's Disease: Understanding Clinical Issues Involved

Importance of Early Detection

Early diagnosis and effective management are crucial to prevent severe complications and enhance the quality of life for those affected.

Short-Term Complications During Active Disease

  • Intestinal Blockages: Due to inflammation and scar tissue formation.
  • Malnutrition: Resulting from nutrient absorption issues.
  • Abscesses and Fistulas: Infected pockets and abnormal connections between intestines and other organs.

Long-Term Complications and Risks

  • Colorectal Cancer: An increased risk associated with chronic inflammation.
  • Arthritis and Skin Conditions: Inflammation can extend beyond the intestines.
  • Liver Disease: Due to the impact of chronic inflammation and medication side effects.

What are Clinical Trials?

Clinical trials are research studies involving people to evaluate medical, surgical, or behavioral interventions. They are essential for discovering new treatments, understanding diseases, and ensuring the safety and efficacy of medical approaches. For Crohn's Disease, clinical trials explore innovative treatment methods, diagnostic tools, and management strategies, offering participants access to cutting-edge therapies.

Why Participate in Clinical Trials?

Participation in clinical trials provides access to new treatments for Crohn's Disease before they become widely available, potentially improving personal health outcomes when standard treatments are inadequate. Participants contribute valuable data that enhances the understanding of Crohn's Disease, facilitating advancements in its management and care. Additionally, clinical trials often offer close monitoring by healthcare professionals, adding an extra layer of medical oversight.

Our Active Studies

  • Arcadia, Monrovia, Pasadena

    Crohn’s Disease Trial

    Coming Soon! Contribute to groundbreaking research by joining our study on Crohn's Disease. We aim to develop effective therapies to enhance quality of life for individuals battling this disease.

    Criteria & Qualifications: • Must be diagnosed with Crohn's Disease.
    • Aged 18 years or older.
    • Willing to adhere to the trial protocol and attend all required appointments.

    Compensation: Contact us for more information

    Read more
  • Crohn's Disease Santa Maria

    Crohn’s Disease Study

    Coming Soon! Contribute to our research targeting Crohn's Disease within the scope of Inflammatory Bowel Disease. Your participation can lead to improved therapies and insights into this challenging condition

    Criteria & Qualifications: • Must be diagnosed with Crohn's Disease.
    • Aged 18 years or older.
    • Willing to participate in clinical research and follow study procedures.

    Compensation: Contact us for more information

    Read more
  • Arcadia, Glendora, Monrovia, Pasadena

    Crohn’s Disease Study

    Crohn’s disease is a chronic inflammatory condition that affects the digestive tract. This clinical trial is being conducted to evaluate the efficacy and safety of guselkumab & golimumab in participants with Crohn’s disease.

    Criteria & Qualifications: • Is at least 18 years of age or older.
    • Diagnosis of Crohn's disease (CD) for at least 3 months.
    • Is willing to provide medical records.

    Compensation: Contact us for more information

    Read more

Frequently Asked Questions

The duration of a clinical trial can differ significantly based on factors like the type of illness and the medication being studied. For instance, when researching treatments for chronic conditions, participants might be monitored for an extended period. Conversely, studies involving antibiotics usually wrap up quickly since patients typically receive treatment for only a few days.


Depending on the study and the study process, in some cases, you will have to keep track of your process, in other cases you will not, but you will have the support and guidance of the research team.

As a research participant, you have the right to drop out of a study at anytime, the right to be given new information about the study, and the right to ask questions at anytime and have them answered promptly.

Even though the primary aim of the study isn't to treat a specific health condition, it might involve clinical procedures like MRI scans, blood tests, or hearing assessments. To perform these and other tests, researchers need to understand the volunteer's overall health status to ensure their safety throughout the clinical study process.

No, you do not have to be a US citizen to participate in a clinical trial. We also do not ask for your social security number. All we ask is that you have a physical address and some form of ID that we can use during the enrollment process.

Sure, you can refer any friend or family member who is willing to participate in a study, for more information click here!

Who is FOMAT Medical Research?

FOMAT Medical Research is California's largest research site network, dedicated to advancing clinical research and improving patient outcomes. With an extensive network of research sites and a relentless commitment to innovating healthcare through diversity, FOMAT Medical Research collaborates with industry Sponsors and CROs to accelerate the development of groundbreaking therapies across multiple therapeutic areas. FOMAT is a founding member of hyperCORE International, a super network of fully professionalized research site organizations.

Join Us in Pioneering Crohn's Disease Research

Our journey is driven by collaboration, innovation, and a relentless pursuit of knowledge. We invite individuals, sponsors, and healthcare professionals to partner with us in this vital quest. Together, we can accelerate the pace of discovery and bring hope to countless lives affected by Crohn's Disease.

Meet Our Experts


Karen Simon, MD

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Camarillo & Oxnard, CA

Dana Y. Pan, MD

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Temple City, CA

Paramjit Benipal, MD

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Santa Maria, CA