Cell-based Therapy for Type 1 Diabetes?
Cell-based Therapy for Type 1 Diabetes has been studied by researchers at Boston Children’s Hospital has successfully reversed type 1 diabetes in a mouse model by infusing blood stem cells pre-treated to produce more of a protein called PD-L1, which is deficient in mice (and people) with type 1 diabetes. The cells curbed the autoimmune reaction in cells from both mice and humans and reversed hyperglycemia in diabetic mice.
Findings were published today in Science Translational Medicine. “There’s really a reshaping of the immune system when you inject these cells,” says Paolo Fiorina, MD, Ph.D., of Boston Children’s, senior investigator on the study.
The study shows that the treated stem cells, given to mice, home to the pancreas where islet cells are made. Almost all the mice were cured of diabetes in the short term, and one-third maintained normal blood sugar levels for the duration of their lives. The treatment was effective whether PD-L1 production was stimulated through gene therapy or pre-treatment with small molecules.